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Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [ 99m Tc] TRODAT‐1
Author(s) -
Chang Ting Ting,
Yeh Tzung Lieh,
Chiu Nan Tsing,
Chen Po See,
Huang Hsiang Yu,
Yang Yen Kuang,
Lee I Hui,
Lu Ru Band
Publication year - 2010
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1111/j.1399-5618.2009.00771.x
Subject(s) - dopamine transporter , dopamine , psychiatry , bipolar disorder , psychology , medicine , neuroscience , cognition , dopaminergic
Chang TT, Yeh TL, Chiu NT, Chen PS, Huang HY, Yang YK, Lee IH, Lu RB. Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [ 99m Tc] TRODAT‐1. Bipolar Disord 2010: 12: 102–106. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S. Objectives: Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients. Methods: Seventeen drug‐free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [ 99m Tc] TRODAT‐1. Results: Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT. Conclusions: Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.