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Olanzapine in the prevention of postpartum psychosis and mood episodes in bipolar disorder
Author(s) -
Sharma Verinder,
Smith Angela,
Mazmanian Dwight
Publication year - 2006
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1111/j.1399-5618.2006.00335.x
Subject(s) - olanzapine , bipolar disorder , mood stabilizer , mood , psychosis , postpartum psychosis , psychology , psychiatry , mood disorders , medicine , schizophrenia (object oriented programming) , anxiety
Objectives: The use of olanzapine (OLZ) in the prevention of postpartum psychosis (PP) and mood episodes in women with bipolar disorder was investigated in a naturalistic, prospective study. Methods: Eleven women received OLZ alone or in combination with an antidepressant or mood stabilizer, and 14 women received either antidepressants, mood stabilizers, or no medication for a minimum of 4 weeks after delivery. Results: Two (18.2%) of the women in the OLZ group experienced a postpartum mood episode, whereas eight (57.1%) of the women in the No‐OLZ group did. Conclusions: The role of OLZ in the prophylaxis of PP and mood episodes, particularly in women at high risk, clearly warrants further investigation.