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von Willebrand's disease and psychotic disorders: co‐segregation and genetic associations
Author(s) -
Lee YuSang,
Miller Mary,
Hassett Andrea Cortese,
LeeKim ByungYeon,
Kim Jung Jin,
Haracznak Michelle,
Ranade Swati,
Wood Joel,
Reddy Ravinder,
Kupfer David J,
Bontempo Franklin,
Nimgaonkar Vishwajit L
Publication year - 2004
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1111/j.1399-5618.2004.00103.x
Subject(s) - transmission disequilibrium test , proband , bipolar disorder , schizophrenia (object oriented programming) , mood disorders , linkage disequilibrium , population , von willebrand disease , psychosis , medicine , psychiatry , clinical psychology , psychology , haplotype , mood , genetics , allele , anxiety , biology , von willebrand factor , mutation , gene , platelet , environmental health
Objectives: To evaluate co‐segregation and genetic associations between von Willebrand's disease (vWD) and psychotic disorders. Methods: The study was initiated following ascertainment of a nuclear family in which four members were diagnosed with vWD and psychotic/mood disorders. As co‐segregation was uncertain in the extended pedigree, we also investigated population‐based linkage and association using polymorphisms of vWF , the gene conferring susceptibility to vWD. Three common vWF polymorphisms were investigated among 194 patients with psychotic disorders (bipolar I disorder, BD I; schizoaffective disorder, SZA and schizophrenia, SZ) and their parents. The cases were also compared with unrelated population‐based controls (n = 183). Results: The transmission disequilibrium test and related analyses suggested nominally significant transmission distortion of one allele and related haplotypes to the probands from their parents. The most significant results were obtained among patients with BD I, and similar trends were also evident in the SZ sample. Comparisons between the cases and population‐based controls did not reveal associations, though marginally significant case–control differences were obtained in the BD I sample. Conclusions: These studies are consistent with association and linkage between vWF and BD I. However, given the relatively small sample, stochastic variation is an alternative explanation.