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Concurrent protracted febrile myalgia syndrome in a child with diabetic ketoacidosis
Author(s) -
Demir Korcan,
Çarman Kürşat B,
Kasap Belde
Publication year - 2012
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-5448.2012.00866.x
Subject(s) - medicine , familial mediterranean fever , mefv , myalgia , pyrin domain , diabetic ketoacidosis , vasculitis , diabetes mellitus , pediatrics , immunology , gene mutation , inflammation , disease , endocrinology , mutation , inflammasome , gene , biochemistry , chemistry
Familial M editerranean Fever ( FMF ), characterized by recurrent attacks of inflammation in predominantly serosal and synovial membranes, is caused by MEFV gene mutations resulting in abnormal pyrin. Protracted febrile myalgia syndrome ( PFMS ), a kind of vasculitis requiring corticosteroid treatment, is associated with M694V mutation of MEFV gene. Here, we report a case where the patient developed PFMS leading to the diagnosis of FMF concurrently at the time of treatment for diabetic ketoacidosis ( DKA ) of new‐onset type 1 diabetes mellitus and discuss the possible mechanisms of simultaneous DKA and FMF ‐associated PFMS . DKA ‐associated cytokine release may be a predisposing factor or trigger for FMF ‐associated PFMS .