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Racial differences in arterial stiffness among adolescents and young adults with type 2 diabetes
Author(s) -
Shah Amy S,
Dolan Lawrence M,
Gao Zhiqian,
Kimball Thomas R,
Urbina Elaine M
Publication year - 2012
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-5448.2011.00798.x
Subject(s) - arterial stiffness , medicine , pulse wave velocity , type 2 diabetes , blood pressure , diabetes mellitus , anthropometry , population , cardiology , risk factor , pulse pressure , endocrinology , environmental health
Shah AS, Dolan LM, Gao Z, Kimball TR, Urbina EM. Racial differences in arterial stiffness among adolescents and young adults with type 2 diabetes. Background: African‐American adults demonstrate a higher prevalence of cardiovascular complications including myocardial infarction and stroke. Whether similar racial disparities are present to suggest African‐Americans adolescents are at higher risk to develop cardiovascular disease is not known. Thus, we compared arterial stiffness, an early marker of cardiovascular disease, in African‐American and Caucasian adolescents and young adults with type 2 diabetes. Methods: Demographic, anthropometric, laboratory data, and arterial stiffness measures including pulse wave velocity (PWV) and augmentation index (AIx) were collected in a cross‐sectional study of 215 adolescents (average age 18 yr) with type 2 diabetes (55% African‐American and 65% female). Results: Compared to Caucasians, African‐Americans had increased PWV (6.21 ± 0.87 vs. 6.96 ± 1.30, p < .01) and AIx (4.44 ± 11.17 vs. 7.64 ± 12.02, p = 0.05). Regression modeling demonstrated age, lipids, blood pressure, and duration of diabetes were differently associated with arterial stiffness in each race group (p < 0.05). Conclusions: African‐American adolescents and young adults with type 2 diabetes have increased vascular stiffness than age‐matched Caucasians. This process is mediated by different cardiovascular risk factors. These results suggest race‐specific risk factor modification may be helpful to prevent early cardiovascular disease in this high risk population.