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Enteroviruses and causality of type 1 diabetes: how close are we?
Author(s) -
DiazHorta Oscar,
Baj Andreina,
Maccari Giuseppe,
Salvatoni Alessandro,
Toniolo Antonio
Publication year - 2012
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-5448.2011.00790.x
Subject(s) - medicine , medical laboratory , library science , family medicine , pathology , computer science
Organ-specific autoimmunity frequently affects the endocrine system,\udincluding pancreatic islets. Type 1 diabetes mellitus (T1D) derives from\udthe autoimmune destruction of insulin-secreting β-cells that is triggered by\udenvironmental factors (1, 2). Genetic predisposition accounts for 36–50%\udof disease susceptibility as demonstrated in monozygotic twin studies\ud(3–5). Approximately 90% of new cases lack a family history of T1D\udindicating a large contribution of exogenous factors to pathogenesis. A\udvariety of associations with viral infections have been reported for human\uddiabetes including rubella, mumps, and cytomegalovirus. However,\udamong investigated agents, human enteroviruses (HEVs) appear to play\uda prominent role (1)