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The interrelationships of glycemic control measures: HbA1c, glycated albumin, fructosamine, 1,5‐anhydroglucitrol, and continuous glucose monitoring
Author(s) -
Beck Roy,
Steffes Michael,
Xing Dongyuan,
Ruedy Katrina,
Mauras Nelly,
Wilson Darrell M,
Kollman Craig
Publication year - 2011
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-5448.2011.00764.x
Subject(s) - fructosamine , glycemic , medicine , continuous glucose monitoring , glycated hemoglobin , diabetes mellitus , endocrinology , albumin , type 2 diabetes
Beck R, Steffes M, Xing D, Ruedy K, Mauras N, Wilson DM, Kollman C, the Diabetes Research in Children Network (DirecNet) Study Group. The interrelationships of glycemic control measures: HbA1c, glycated albumin, fructosamine, 1,5‐anhydroglucitrol, and continuous glucose monitoring. Objectives: To describe the interrelationships of glycemic control measures: hemoglobin A1c (HbA1c), glycated albumin, fructosamine, 1,5‐anhydroglucitrol (1,5‐AG), and continuous glucose monitoring (CGM) in children and adolescents with type 1 diabetes. Methods: In total, 26 subjects of age 4–17 had HbA1c measurement followed within 14 d by three laboratory measures of glycemia and the collection of CGM glucose data (N = 21). Results: Glycated albumin and fructosamine levels had a higher correlation with each other than with HbA1c. The correlation of 1,5‐AG with HbA1c was lower (absolute r value = 0.25). All four measures had a similar degree of correlation with CGM‐measured mean glucose (absolute r value = 0.50–0.56) and with hyperglycemic area under the curve (AUC) at 180 mg/dL (0.50–0.60). Conclusion: Each of the four measures (i.e., HbA1c, glycated albumin, fructosamine, and 1,5‐AG) had a similar correlation with mean glucose and hyperglycemic AUC‐180. 1,5‐AG did not correlate with hyperglycemic AUC‐180 better than did HbA1c.