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Parenteral insulin suppresses T cell proliferation to islet antigens
Author(s) -
Greenbaum Carla J,
McCullochOlson Marli,
Chiu Harvey K,
Palmer Jerry P,
BrooksWorrell Barbara
Publication year - 2011
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-5448.2010.00674.x
Subject(s) - islet , insulin , medicine , diabetes mellitus , cell growth , antigen , endocrinology , regimen , type 1 diabetes , immunology , biology , biochemistry
Greenbaum CJ, McCulloch‐Olson M, Chiu HK, Palmer JP, Brooks‐Worrell B. Parenteral insulin suppresses T cell proliferation to islet antigens. The diabetes prevention trial‐type 1 (DPT‐1) tested whether a combination of SQ and IV insulin therapy would delay the onset of disease in individuals at high risk of progression. We investigated whether this regimen altered T cell responses to human islet proteins using cellular immunoblotting. Among the 10 treated and 7 control subjects studied, we found that there was a significant effect of treatment on cellular immunoblotting responses. We conclude that parenteral insulin may suppress proliferation to islet antigens in individuals at risk for diabetes, but this effect may be transient. Further study is needed to determine whether a therapy that results in sustained suppression of T cell proliferation could yield a measurable clinical benefit.