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Does the relative risk for type 1 diabetes conferred by HLA‐DQ, INS , and PTPN22 polymorphisms vary with maternal age, birth weight, or cesarean section?
Author(s) -
Stene Lars C,
Rønningen Kjersti S,
Undlien Dag E,
Joner Geir
Publication year - 2011
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-5448.2010.00669.x
Subject(s) - medicine , ptpn22 , relative risk , type 2 diabetes , birth weight , confidence interval , type 1 diabetes , obstetrics , diabetes mellitus , population , logistic regression , pregnancy , genotype , endocrinology , single nucleotide polymorphism , genetics , biology , gene , environmental health
Stene LC, Rønningen KS, Undlien DE, Joner G. Does the relative risk for type 1 diabetes conferred by HLA‐DQ, INS , and PTPN22 polymorphisms vary with maternal age, birth weight, or cesarean section? Background and objective: Maternal age at birth, birth weight, and cesarean section has been associated with a weak but significant increase in risk of type 1 diabetes. The objective was to assess whether the relative risk for type 1 diabetes conferred by established susceptibility loci human leukocyte antigen (HLA)‐DQ, INS , and PTPN22 differed depending on these perinatal factors. Methods: We employed a case–control study with 456 cases of type 1 diabetes diagnosed before 15 yr of age and 1377 population‐based control children. HLA genotypes were divided into high to moderate risk (DQ8/DQ2, DQ8/DQ8, DQ8/X, DQ2/DQ2) vs. all other genotypes. Case‐only analysis using logistic regression was used to test for significant interaction. Results: There was no significant difference in the relative risks conferred by HLA‐DQ, INS, or PTPN22 by maternal age, birth weight, or mode of delivery, except the relative risk conferred by PTPN22 which was 2.11 [95% confidence interval (CI): 1.64–2.72] for those born vaginally and 0.99 (95% CI: 0.50–1.99) for those born by cesarean section [p(interaction) = 0.028]. Conclusion: The relative risks conferred by the three established susceptibility genes investigated here were independent of the perinatal factors, apart from a possible interaction between PTPN22 and mode of delivery.