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The influence of physical activity on ghrelin and IGF‐1/IGFBP‐3 levels in children and adolescents with type 1 diabetes mellitus
Author(s) -
Huber Julia,
FröhlichReiterer Elke Elisabeth,
Sudi Karl,
Suppan Elisabeth,
Weinhandl Gudrun,
JasserNitsche Hildegard,
Aigner Reingard,
Borkenstein Martin Helmuth
Publication year - 2010
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-5448.2009.00604.x
Subject(s) - medicine , ghrelin , type 2 diabetes mellitus , endocrinology , physical activity , diabetes mellitus , physical therapy , hormone
Huber J, Fröhlich‐Reiterer EE, Sudi K, Suppan E, Weinhandl G, Jasser‐Nitsche H, Aigner R, Borkenstein MH. The influence of physical activity on ghrelin and IGF‐1/IGFBP‐3 levels in children and adolescents with type 1 diabetes mellitus. Objectives: The aim of the study was to determine the influence of regular physical activity on ghrelin and IGF‐1/IGFBP‐3 levels during a diabetes camp. Methods: Twenty‐eight children and adolescents (14 boys; mean age 12.1 yr) with type 1 diabetes mellitus (T1DM, mean duration of diabetes 4.8 yr) attending a 2‐wk diabetes camp that features increased regular physical activities have been studied. Serum levels of ghrelin (total and acylated), growth hormone (GH), insulin‐like growth factor‐1 (IGF‐1), insulin‐like growth factor‐bindng protein‐3 (IGFBP‐3) and insulin were measured in fasting state on day 1 and day 14. Improvement of metabolic control was documented by haemoglobin A1c (HbA1c). Glucose levels and insulin doses were determined daily. Results: Mean insulin dosage decreased from 0.87 to 0.78 U/kg/d, mean HbA1c levels decreased from 8.6 to 8.3%, but the changes were not statistical. There was a significant decline in total ghrelin. IGFBP‐3 and IGF‐1 decreased also significantly. Total basal ghrelin was inversely related to the change in IGFBP‐3. Conclusions: We hypothesize an association between ghrelin and metabolic control in T1DM. Higher ghrelin levels might be associated with poor metabolic control. The dynamic of IGFBP‐3 levels appears to be under the influence of basal ghrelin concentrations in T1DM.