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Obesity and family history of diabetes as risk factors of impaired fasting glucose: implications for the early detection of prediabetes
Author(s) -
RodríguezMoran Martha,
GuerreroRomero Fernando,
AradillasGarcía Celia,
Violante Rafael,
SimentalMendia Luis E,
MonrealEscalante Elizabeth,
De La Cruz Mendoza Esperanza
Publication year - 2010
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-5448.2009.00590.x
Subject(s) - prediabetes , medicine , impaired fasting glucose , diabetes mellitus , obesity , family history , impaired glucose tolerance , endocrinology , type 2 diabetes
Rodríguez‐Moran M, Guerrero‐Romero F, Aradillas‐García R, Simental‐Mendia LE, Monreal‐Escalante E, de la Cruz Mendoza E. Obesity and family history of diabetes as risk factors of impaired fasting glucose: implications for the early detection of prediabetes. Objective: To determine whether the association between family history of diabetes (FHD) and impaired fasting glucose (IFG) is independent of body mass index (BMI) in children and adolescents. Methods: In all 443 (11.9%) children and adolescents with FHD, and 3280 (88.1%) without FHD were enrolled in a population‐based cross‐sectional study. Eligible subjects to participate were apparently healthy children and adolescents aged 7–15 yr from Middle and Northern Mexico. Obesity was defined by age‐ and gender‐specific BMI ≥ 95th percentile. FHD was defined as positive if at least one first degree relative had diabetes. The IFG was defined by fasting plasma glucose ≥ 100 mg/dL and < 126 mg/dL. Results: IFG was identified in 390 (88.0%) and 62 (1.9%) children and adolescents with and without FHD, respectively. In the group with positive FHD, IFG was diagnosed in 146 (37.4%), 79 (20.2%), and 165 (42.3%) children and adolescents who were obese, overweight, and normal‐weight, respectively. On the other hand, in the group without FHD, IFG was identified in 21 (33.9%), 14 (22.6%), and 27 (43.5%) children and adolescents who were obese, overweight, and normal‐weight, respectively. In the overall population, the age‐, sex‐, and BMI‐adjusted logistic regression analysis showed a strong and independent association between FHD and IFG [odds ratio (OR) −11.7; 95% CI 9.5–21.2]. This association remained strong for girls and boys in a subsequent analysis stratified for BMI category. Conclusions: The presence of FHD in a first degree relative is associated with IFG, even in the absence of obesity.