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Association of waist circumference, traditional cardiovascular risk factors, and stromal‐derived factor‐1 in adolescents
Author(s) -
Jung Christian,
Fischer Nicole,
Fritzenwanger Michael,
Pernow John,
Brehm Bernhard R,
Figulla Hans R
Publication year - 2009
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-5448.2008.00486.x
Subject(s) - medicine , waist , adiponectin , body mass index , overweight , percentile , metabolic syndrome , blood pressure , risk factor , obesity , insulin resistance , endocrinology , statistics , mathematics
Background: Overweight and the metabolic syndrome (MS) represent dramatically increasing problems in children and adolescents. Waist circumference (WC) is an important factor to determine MS. So far, WC is a predictor of blood pressure, high‐density lipoprotein (HDL), insulin concentration, and visceral fat in adolescents. We investigated whether WC and body mass index standard deviation score (BMI‐SDS) are predictors of adiponectin, stromal‐derived factor (SDF‐1), and soluble E‐selectin (sE‐selectin) as parameters for beginning insulin resistance and endothelial damage. Methods: Seventy‐nine male Caucasian adolescents were studied, aged 13–17 yr. Thirty‐eight (48%) of them had a WC above 90th age percentile. All participants were enrolled in one consultation, recording various parameters and collecting one blood sample. Results: Differences in systolic blood pressure, HDL, high sensitive C‐reactive protein, and hemoglobin A1c could be found between groups above or below the 90th WC percentile. Linear regression analysis revealed that WC and BMI‐SDS predict traditional risk factors, as well as reduced adiponectin, lower SDF‐1, and higher sE‐selectin levels. Multiple linear regression analyses show that SDF‐1 is in closest correlation to WC and BMI‐SDS. Conclusions: WC and BMI‐SDS predict various alterations of traditional and new cardiovascular risk factors. SDF‐1 might be a new marker for diagnosis of obesity‐related diseases and help understand pathophysiologic mechanisms.