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Insulin‐related metabolism following hematopoietic stem cell transplantation in childhood
Author(s) -
Elhasid Ronit,
Leshem Yael A,
Ben Arush Myriam Weyl,
Rowe Jacob M,
Shehadeh Naim
Publication year - 2009
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-5448.2008.00420.x
Subject(s) - medicine , hematopoietic stem cell transplantation , insulin , hemoglobin , transplantation , diabetes mellitus , endocrinology , gastroenterology , insulin resistance , cohort
Objectives: To assess insulin‐related metabolism following hematopoietic stem cell transplantation (HSCT) in childhood. Study design: Thirty‐four patients who underwent HSCT were compared with 21 patients with similar diseases who were not transplanted. Median follow‐up was 3.6 yr after HSCT. Anthropometric parameters, fasting plasma glucose and insulin levels, hemoglobin A 1c (HbA 1c ) and lipid profile were measured and compared. Results: HbA 1c was significantly higher (p = 0.001) in the study group. Two (5.8%) patients in the study group developed type 2 diabetes mellitus. Among thalassemic patients, significantly lower insulin resistance indices (p = 0.05) and fasting plasma insulin levels (p = 0.033) were found in the study group compared with the control group. Conclusions: Attentive follow‐up of insulin‐related metabolism following HSCT in children is needed. The significance of the higher HbA1c values in the study group remains to be evaluated in a larger cohort of patients.