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Antioxidant level and redox status of coenzyme Q 10 in the plasma and blood cells of children with diabetes mellitus type 1
Author(s) -
Menke Thomas,
Niklowitz Petra,
Wiesel Thomas,
Andler Werner
Publication year - 2008
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-5448.2008.00389.x
Subject(s) - diabetes mellitus , medicine , antioxidant , oxidative stress , coenzyme q – cytochrome c reductase , redox , endocrinology , antioxidant capacity , type 1 diabetes , coenzyme q10 , pathogenesis , oxidative phosphorylation , blood plasma , mitochondrion , biochemistry , chemistry , cytochrome c , organic chemistry
Hyperglycaemia has been reported to cause increased production of oxygen free radicals. Oxidative stress may contribute to the pathogenesis of diabetic complications. Coenzyme Q 10 (CoQ 10 ) is known for its key role in mitochondrial bioenergetics and is considered as a potent antioxidant and free radical scavenger. This study was conducted to evaluate plasma and blood cell concentrations of CoQ 10 in accordance to its redox capacity in children with diabetes mellitus type 1. CoQ 10 plasma and blood cell concentrations and redox status were measured using high‐performance liquid chromatography with electrochemical detection in 43 children with diabetes mellitus type 1 and compared with 39 healthy children. In addition, the diabetic patients were subdivided according to their haemoglobin A1c (HbA1c) values into two groups, that is, those with good control (<8%) and those with poor control (>8%), and the CoQ 10 status was compared between the two groups. Children with type 1 diabetes showed increased plasma levels of CoQ 10 in comparison to healthy children. While CoQ 10 erythrocyte and platelet concentrations did not differ, in the diabetes group, the platelet redox status differed with a significantly increased part of reduced CoQ 10 . This difference in concentration and redox status in comparison to healthy controls may be attributed to the subgroup of patients with poor control, as the subdivision of diabetic patients according to their HbA1c values shows. In diabetic children, especially in those with poor control, an increase in plasma concentration and intracellular redox capacity of the antioxidant CoQ 10 may contribute to the body’s self‐protection during a state of enhanced oxidative stress.