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Perinatal risk factors for early childhood onset type 1 diabetes in Austria – a population‐based study (1989–2005)
Author(s) -
Waldhoer Thomas,
Rami Birgit,
Schober Edith
Publication year - 2008
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-5448.2008.00378.x
Subject(s) - medicine , hazard ratio , birth weight , confidence interval , pediatrics , population , incidence (geometry) , gestational age , gestational diabetes , cohort study , body mass index , obstetrics , type 1 diabetes , diabetes mellitus , pregnancy , gestation , endocrinology , physics , environmental health , biology , optics , genetics
Background: To investigate the rapid increase in incidence of type 1 diabetes mellitus (T1DM) in children <5 yr in Austria. Methods: Data of children born between 1989 and 2005 (n = 444) from the T1DM children incidence registry were linked with birth certificates (n = 1 407 829). Results: Age of mother, level of education, birth weight, birth length, body mass index, and APGAR score at 10 min were not significant. Boys have about 25% higher risk than girls [hazard ratio = 0.75, 95% confidence interval (CI): 0.62–0.91]. The risk of developing diabetes increases over time significantly (1989–1991 vs. 2001–2005, hazard ratio = 2.86, 95% CI: 2.07–3.94). The linear effect of parity is borderline significant (p = 0.045), with lower risks for second and later born siblings. Marital status is significant [hazard ratio = 0.73, 95% CI: 0.57–0.90)]. Native‐born children exhibit twice as high risk as non‐native children (hazard ratio = 0.51, 95% CI: 0.37–0.71). Birth weight shows a positive but not significant effect on risk of T1DM. Conclusions: In this very young and rapidly increasing cohort of diabetic children <5 yr of age, no association with birth weight but with year of birth, gestational age, nationality and parity could be observed.