Premium
Impaired glucose tolerance and risk factors for progression to type 2 diabetes in youth
Author(s) -
Weiss Ram
Publication year - 2007
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-5448.2007.00336.x
Subject(s) - prediabetes , medicine , insulin resistance , impaired glucose tolerance , obesity , type 2 diabetes , endocrinology , metabolic syndrome , impaired fasting glucose , diabetes mellitus , carbohydrate metabolism
Impaired glucose tolerance and impaired fasting glucose represent two potentially reversible prediabetes conditions. Previous reports from various regions across the globe indicate that both conditions may be relatively common in obese children and adolescents. The major factor driving the development of compromised glucose metabolism in obese youth is severe insulin resistance. This severe insulin resistance has been strongly associated with specific patterns of lipid partitioning. Severe obesity along with continued weight gain, specifically in obese youth belonging to ethnic minorities, have been shown to be associated with deterioration of glucose tolerance over short periods of time. As obesity‐related insulin resistance in the pediatric age‐group is associated with the development of altered glucose metabolism and other elements of the metabolic syndrome, severely obese youth are a high‐risk group for the development of type 2 diabetes and may benefit most from preventive interventions such as environmental changes that promote increased physical activity.