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Continuous subcutaneous insulin infusion benefits quality of life in preschool‐age children with type 1 diabetes mellitus
Author(s) -
OpipariArrigan Lisa,
Fredericks Emily M,
Burkhart Nugget,
Dale Linda,
Hodge Mary,
Foster Carol
Publication year - 2007
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-5448.2007.00283.x
Subject(s) - medicine , type 1 diabetes , worry , quality of life (healthcare) , diabetes mellitus , psychosocial , pediatrics , adverse effect , insulin , randomized controlled trial , insulin pump , endocrinology , anxiety , nursing , psychiatry
Objective: To compare medical, nutritional, and psychosocial outcomes of continuous subcutaneous insulin infusion (CSII) therapy and multiple daily insulin injections (MDI) in preschoolers with type 1 diabetes mellitus (T1DM) in a randomized controlled trial. Study design: Sixteen children (mean age 4.4 ± 0.7 yr, range 3.1–5.3 yr) with T1DM were randomly assigned to CSII or MDI. Hemoglobin A1c (HbA1c) was measured monthly for 6 months. Glucose variability was measured at baseline and at 6 months using continuous blood glucose sensing. Quality of life, adverse events, and nutrition information were assessed. Results: Parents of the CSII group reported a significant decrease in diabetes‐related worry, while parents of the MDI group reported an increased frequency of stress associated with their child’s medical care. Mean HbA1c levels from baseline (CSII 8.3 ± 1.4%, MDI 8.0 ± 0.8%) to 6 months (CSII 8.4 ± 0.8%, MDI 8.2 ± 0.4%) remained stable, and group differences were not significant. There were no significant group differences in duration of hypo‐ or hyperglycemic events or frequency of adverse events. Conclusion(s): For young children with T1DM, CSII therapy is comparable to MDI therapy with regard to glucose control but is associated with higher treatment satisfaction and improved quality of life.