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Serum 1,5‐anhydroglucitol (Glycomark™) levels in children with and without type 1 diabetes mellitus
Author(s) -
Nguyen Thanh M,
Rodriguez Luisa M,
Mason Kimberly J,
Heptulla Rubina A
Publication year - 2007
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-5448.2007.00228.x
Subject(s) - postprandial , medicine , fructosamine , type 1 diabetes , glycemic , glycated hemoglobin , endocrinology , diabetes mellitus , type 2 diabetes mellitus , type 2 diabetes
Postprandial hyperglycemia associated with diabetes is a risk factor for cardiovascular disease. Currently, glycated hemoglobin A 1c (HgbA 1c ) and glycated protein fructosamine are not sensitive markers for acute and short‐term hyperglycemia. 1,5‐Anhydroglucitol (1,5‐AG) (Glycomark™; Tomen America, New York, NY, USA) is reported in adults with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) as a marker for postmeal hyperglycemia. However, the reference ranges for 1,5‐AG in normal children and children with T1DM are not known. We studied 1,5‐AG levels in 10 control children (6 males and 4 females) and 10 children with T1DM (7 males and 3 females). The levels of 1,5‐AG in the normal controls were higher than those in children with T1DM (24.60 ± 3.99 μg/mL vs. 4.75 ± 2.95 μg/mL; p < 0.0001). There were no gender differences noted. The 1,5‐AG levels were negatively correlated with HgbA 1c (r =−0.9366; p < 0.0001) and the peak postmeal plasma glucose concentrations (Pearson r =−7230; p = 0.0003). Our findings suggest that despite good glycemic control, postprandial glucose concentrations are elevated and that 1,5‐AG showed a difference between controls and children with T1DM. The data are comparable with previous studies in normal adults and in those with T1DM and T2DM. They support the use of 1,5‐AG concentrations, together with HgbA 1c , to evaluate therapy, especially to target postprandial hyperglycemia.