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Adult‐like but regressive increase of intima‐media thickness and roughness in a child with type 1 diabetes
Author(s) -
Krebs Andreas,
SchmidtTrucksäss Arno,
Wagner Julia,
Krebs Kristin,
Doerfer Jürgen,
Schwab Karl Otfried
Publication year - 2005
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-543x.2005.00121.x
Subject(s) - medicine , intima media thickness , diabetes mellitus , cardiology , tunica media , common carotid artery , subclinical infection , type 2 diabetes , type 1 diabetes , carotid arteries , endocrinology
Abstract: A 12‐yr‐old Kosovo‐Albanian boy with insufficiently controlled type 1 diabetes since his second year of life developed severely increased intima‐media thickness (IMT) and roughness (IMR) of the common carotid artery (CCA): max/mean IMT = 0.81/0.68 mm and IMR = 0.048 mm. Intima‐media thickening, comparable with that in a 50‐ to 60‐yr‐old healthy adult, decreased within 41 months (max/mean carotid IMT = 0.72/0.56 mm and IMR = 0.036 mm) by intensive treatment of diabetes. Moyamoya disease (MMD), complicated by cerebral infarction, occurred coincidentally but regressed within 6 months. This case report points out that (i) chronic hyperglycemia in childhood may lead to adult‐like increase of carotid IMT/IMR as early signs of subclinical atherosclerosis, (ii) increased carotid IMT/IMR may be regressive by intensive diabetes control, and (iii) a screening examination for carotid IMT/IMR should be considered in patients at high risk of atherosclerosis.