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Diabetes in an infant with cystic fibrosis
Author(s) -
Lombardi Francesca,
Raia Valeria,
Spagnuolo Maria Immacolata,
Nugnes Rosa,
Valerio Giuliana,
Ciccarelli Giuseppe,
Franzese Adriana
Publication year - 2004
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/j.1399-543x.2004.00069.x
Subject(s) - medicine , cystic fibrosis , diabetes mellitus , complication , cystic fibrosis related diabetes , disease , insulin , pulmonary function testing , pediatrics , endocrinology , intensive care medicine , impaired glucose tolerance , insulin resistance
Cystic fibrosis (CF)‐related diabetes mellitus is an unusual complication in very young pediatric patients with CF. It is generally associated with more severe clinical manifestations of CF. In this report, we describe a case of diabetes and CF starting in infancy. The patient manifested a form of intermittent diabetes without fasting hyperglycemia, which was exacerbated by steroid treatment during pulmonary disease and occasionally required insulin therapy. Insulin responses to oral and intravenous glucose challenge were low. The clinical and radiological status was stable during the 9‐yr follow‐up. Our patient demonstrates that diabetes may not only represent a complication of CF, as previously maintained, but can also be a co‐morbid condition proceeding along with the exocrine disease. The early occurrence of hyperglycemia in this case may highlight an impairment of β‐cell function, which might be genetically determined. Careful monitoring of the glucose profile and of β‐cell function is indicated in patients with CF to avoid late recognition of diabetes.