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Reference values for clinical chemistry and clinical hematology parameters in cynomolgus monkeys
Author(s) -
Schuurman HenkJan,
Smith Harold T
Publication year - 2005
Publication title -
xenotransplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.052
H-Index - 61
eISSN - 1399-3089
pISSN - 0908-665X
DOI - 10.1111/j.1399-3089.2004.00186.x
Subject(s) - hematology , tolerability , xenotransplantation , nonhuman primate , medicine , clinical trial , in vivo , physiology , reference values , biology , pathology , transplantation , adverse effect , evolutionary biology , microbiology and biotechnology
Background: In vivo xenotransplantation modeling in large animal species is often performed in nonhuman primates, including baboons. For proper data interpretation, reference values for clinical chemistry and hematology are required. Methods: These values are available from baseline levels in animals subjected to tolerability/pharmacokinetic studies. For each individual study two tests for clinical chemistry and hematology were performed before the start of treatment. Results and conclusion: Baseline levels were determined in 27 males and 15 females, in total 106 determinations (53 in males, and 53 in females). For a number of parameters levels in cynomolgus monkeys show clear differences from those in baboons. These data are reported here to provide baseline values for veterinarians and investigators using nonhuman primates in experimental studies.