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High‐affinity anti‐Gal immunoglobulin G in chronic rejection of xenografts
Author(s) -
Galili Uri,
Minanov Oktavijan P.,
MlchSer Robert E.,
Stone Kevin R.
Publication year - 1997
Publication title -
xenotransplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.052
H-Index - 61
eISSN - 1399-3089
pISSN - 0908-665X
DOI - 10.1111/j.1399-3089.1997.tb00175.x
Subject(s) - immunogenicity , antibody , epitope , antigen , immune system , immunoglobulin g , immunology , cytotoxicity , chemistry , transplantation , microbiology and biotechnology , biology , medicine , in vitro , biochemistry
The immune system in humans and monkeys responds vigorously against α‐gal (α‐galactosyl, Galα1‐3Galβ1‐4GIcNAc‐R) epitopes on xenografts by producing large amounts of high‐affinity anti‐Gal immunoglobulin G molecules. These antibody molecules may exacerbate chronic rejection of xenografts via several mechanisms including: antibody‐dependent cell cytotoxicity, chronic activation of endothelial cells, and increasing immunogenicity of xenograft‐specific antigens by targeting them to antigen‐presenting cells.