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Tissue culture prevents hyperacute rejection of islet xenografts
Author(s) -
Gray D.W.R.,
Song Z.,
Glover L.,
Welsh K.I.,
Morris P.J.
Publication year - 1995
Publication title -
xenotransplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.052
H-Index - 61
eISSN - 1399-3089
pISSN - 0908-665X
DOI - 10.1111/j.1399-3089.1995.tb00085.x
Subject(s) - islet , transplantation , pancreas , cadaveric spasm , xenotransplantation , medicine , diabetes mellitus , graft rejection , bioinformatics , biology , surgery , endocrinology
Despite some notable successes in recent years, it has become clear that the use of human islets of the purpose of curing diabetes by isle transplantation is not a practical solution for the treatment of the large number of diabetic patients who could potentially benefit from such a procedure. The major reason for this conclusion is that the yield of islets obtainable from the average human pancreas is relatively low, and the numbers of suitable human cadaveric donors are few. By using islets obtained from the pancreas of an ethically acceptable nonhuman donor such as the pig, it should be easily possible to obtain sufficient islet tissue to transplant as many patients as necessary, but the problems of tissue availability are replaced by those of xenograft rejection.