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Fatal human metapneumovirus and influenza B virus coinfection in an allogeneic hematopoietic stem cell transplant recipient
Author(s) -
Ghattas C.,
Mossad S.B.
Publication year - 2012
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2012.00766.x
Subject(s) - coinfection , human metapneumovirus , medicine , septic shock , immunology , neutropenia , hematopoietic stem cell transplantation , pneumonia , virus , virology , sepsis , respiratory system , transplantation , respiratory tract infections , toxicity
Human metapneumovirus ( hMPV ) infection can occur in all age groups with significant morbidity and mortality. Coinfection with influenza virus occurs mainly with influenza type A and all reported cases recovered completely. We report the case of a 61‐year‐old man who had hematopoietic stem cell transplant for myelodysplastic syndrome. He was admitted to hospital for septic shock and neutropenia, and blood culture was positive for P seudomonas aeruginosa . He rapidly developed respiratory failure and required ventilator support. His respiratory culture grew P . aeruginosa and hMPV . His course was complicated by persistent shock requiring vasopressor support, and repeat nasopharyngeal swab was positive for influenza type B and hMPV . His condition rapidly deteriorated, his family elected comfort care, and the patient died shortly thereafter. Coinfection with hMPV and influenza virus type B may have a poor outcome and can be fatal, especially in immunocompromised patients.