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Donor‐derived organ transplant transmission of coccidioidomycosis
Author(s) -
Dierberg K.L.,
Marr K.A.,
Subramanian A.,
Nace H.,
Desai N.,
Locke J.E.,
Zhang S.,
Diaz J.,
Chamberlain C.,
Neofytos D.
Publication year - 2012
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2011.00696.x
Subject(s) - medicine , immunosuppression , transmission (telecommunications) , organ transplantation , disease , solid organ , immunology , antifungal , transplantation , pathology , dermatology , electrical engineering , engineering
Coccidioidomycosis in solid organ transplant recipients most often occurs as a result of primary infection or reactivation of latent infection. Herein, we report a series of cases of transplant‐related transmission of coccidioidomycosis from a single donor from a non‐endemic region whose organs were transplanted to 5 different recipients. In all, 3 of the 5 recipients developed evidence of C occidioides infection, 2 of whom had disseminated disease. The degree of T‐cell immunosuppression and timing of antifungal therapy initiation likely contributed to development of disease and disease severity in these recipients. This case series highlights the importance of having a high index of suspicion for C occidioides infection in solid organ transplant recipients, even if the donor does not have known exposure, given the difficulties of obtaining a detailed and accurate travel history from next‐of‐kin.