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Presumed cytomegalovirus‐associated retrobulbar optic neuritis in a patient after allogeneic stem cell transplantation
Author(s) -
Zheng X.,
Huang Y.,
Wang Z.,
Yan H.,
Pan S.,
Wang H.
Publication year - 2012
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2011.00678.x
Subject(s) - medicine , optic neuritis , methylprednisolone , pleocytosis , cytomegalovirus , transplantation , immunosuppression , hematopoietic stem cell transplantation , surgery , optic nerve , stem cell , multiple sclerosis , ophthalmology , meningitis , immunology , herpesviridae , viral disease , virus , genetics , biology
A case of cytomegalovirus ( CMV )‐associated bilateral retrobulbar optic neuritis ( ON ) following haploidentical hematopoietic stem cell transplantation (haplo‐ HSCT ) is reported. Abrupt onset of bilateral decreased vision occurred in a 33‐year‐old man 7 months after haplo‐ HSCT . His cerebrospinal fluid ( CSF ) demonstrated pleocytosis with an absence of leukemic cells. CMV DNA was detected in his blood and CSF sample. Neither encephalopathy nor retinopathy was found in this patient. He was diagnosed with bilateral retrobulbar ON . Although he was given enough antiviral treatment against CMV and immunosuppression with high‐dose methylprednisolone, the patient's vision showed no improvement, and he has almost total bilateral blindness. This is the first report, to our knowledge, of CMV ‐associated bilateral retrobulbar ON in allogeneic stem cell transplantation.