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Lessons from a transplant patient with diarrhea, cryptosporidial infection, and possible mycophenolate mofetil‐associated colitis
Author(s) -
Frei P.,
Weber A.,
Geier A.,
Mertens J.C.,
Kohler S.,
Rogler G.,
Müllhaupt B.
Publication year - 2011
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2011.00653.x
Subject(s) - medicine , diarrhea , mycophenolate , colitis , gastroenterology , adverse effect , transplantation , immunology
P. Frei, A. Weber, A. Geier, J.C. Mertens, S. Kohler, G. Rogler, B. Müllhaupt. Lessons from a transplant patient with diarrhea, cryptosporidial infection, and possible mycophenolate mofetil‐associated colitis.
Transpl Infect Dis 2011: 13: 416–418. All rights reserved Abstract: Diarrhea in a transplant recipient may be caused by infection, metabolic problems, or adverse drug effects. The immunosuppressive drug most frequently associated with diarrhea in transplant recipients is mycophenolate mofetil (MMF). We present the case of a patient with 2 potential explanations for diarrhea lasting several weeks, which occurred years after liver transplantation. Whereas stool samples were positive for cryptosporidia, the histopathological findings were compatible with MMF colitis. However, diarrhea resolved after treatment of cryptosporidial infection, despite continued MMF medication. This case shows that histopathological findings of MMF colitis may be misleading and do not prove that diarrhea is drug induced.