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A novel combination regimen for the treatment of refractory bacteremia due to multidrug‐resistant Pseudomonas aeruginosa in a liver transplant recipient
Author(s) -
Sun H.Y.,
Shields R.K.,
Cacciarelli T.V.,
Muder R.R.,
Singh N.
Publication year - 2010
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2010.00543.x
Subject(s) - medicine , bacteremia , regimen , multiple drug resistance , pseudomonas aeruginosa , refractory (planetary science) , antimicrobial , tobramycin , liver transplantation , drug resistance , microbiology and biotechnology , antibiotics , transplantation , bacteria , genetics , astrobiology , biology , physics
H.‐Y. Sun, R.K. Shields, T.V. Cacciarelli, R.R. Muder, N. Singh. A novel combination regimen for the treatment of refractory bacteremia due to multidrug‐resistant Pseudomonas aeruginosa in a liver transplant recipient
Transpl Infect Dis 2010: 12: 555–560. All rights reserved Abstract: Both bacteremia and biliary cast syndrome are serious post‐transplant complications in liver transplant recipients. In the setting of increasing drug resistance in the current era, management of infections caused by multidrug‐resistant (MDR) bacteria has proven challenging. We present a case of a liver transplant recipient who developed biliary cast syndrome and intractable MDR Pseudomonas bacteremia that failed to resolve with conventional antimicrobial therapy and which was finally controlled by a novel combination regimen of colistimethate, doripenem, and tobramycin. Future studies validating the clinical efficacy of this combination strategy are warranted.