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Disseminated adenovirus infection in renal transplant recipients: the role of cidofovir and intravenous immunoglobulin
Author(s) -
Saquib R.,
Melton L.B.,
Chandrakantan A.,
Rice K.M.,
Spak C.W.,
Saad R.D.,
Fenves A.Z.,
Barri Y.M.
Publication year - 2010
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2009.00452.x
Subject(s) - medicine , cidofovir , antibody , renal transplant , immunology , virology , transplantation , virus
R. Saquib, L.B. Melton, A. Chandrakantan, K.M. Rice, C.W. Spak, R.D. Saad, A.Z. Fenves, Y.M. Barri. Disseminated adenovirus infection in renal transplant recipients: the role of cidofovir and intravenous immunoglobulin.
Transpl Infect Dis 2010: 12: 77–83. All rights reserved Abstract: Disseminated adenovirus (ADV) infection in solid organ transplant patients is associated with high mortality. Limited studies have shown benefit from using cidofovir (CDV), as well as intravenous immunoglobulin (IVIG). In this study, we report 2 renal transplant patients who presented with fever and pulmonary infiltrates. Both patients continued to worsen despite antibiotic therapy. Bronchoalveolar lavage viral culture and serum polymerase chain reaction (PCR) were positive for ADV. Patients were treated with CDV, IVIG, and reduction in immunosuppression. A progressive decline in serum ADV DNA by PCR correlated with clinical improvement and pulmonary infiltrates improved. Both patients recovered. Allograft function was preserved although reversible acute kidney injury was observed in both patients. To the best of our knowledge, this is the first successful use of CDV and IVIG in renal transplant patients with disseminated ADV infection.

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