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High rate of infection and immune disorders in patients with hepatitis C virus after liver transplantation
Author(s) -
Micheloud D.,
Salcedo M.,
Bañares R.,
Rincón D.,
Jensen J.,
Rodríguez J.J.,
FernándezCruz E.,
Carbone Campoverde J.,
Resino S.
Publication year - 2009
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2009.00408.x
Subject(s) - medicine , hepatitis c virus , liver transplantation , etiology , gastroenterology , hepatitis c , incidence (geometry) , immunology , prospective cohort study , transplantation , virus , physics , optics
The aim of this prospective study was to analyze the incidence of serious infections and changes in immunological markers after liver transplantation (LT) in a cohort of patients with hepatitis C virus (HCV). This study included 34 patients who had LT, 20 patients with HCV etiology (HCV group), and 14 patients with alcoholic etiology (non‐HCV group). Patients with HCV were more likely to have severe infections (80%) in comparison with patients in the non‐HCV group (42%) ( P =0.05). The HCV group had a 3‐fold greater likelihood of early severe bacterial infections than the non‐HCV group. At 1 week post LT, the HCV group showed higher values of CD19+ B cells/μL than the non‐HCV group ( P <0.05). At weeks 4 and 12 post LT, the HCV group had lower values of CD19+ B cells/μL ( P <0.05). Our data suggest that HCV recurrence after LT was associated with a high incidence of early severe infections and immunological alterations, which may be related to this increased risk.