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Synergistic effect of carbapenem–teicoplanin combination during severe Rhodococcus equi pneumonia in a kidney transplant recipient
Author(s) -
El Karoui K.,
Guillet C.,
Sekkal N.,
Lanternier F.,
Méchaï F.,
Hue K.,
Hiesse C.,
Mamzer Bruneel M.F.,
Catherinot E.,
Viard J.P.,
Mainardi J.L.,
Lecuit M.,
Ferroni A.,
Lortholary O.
Publication year - 2009
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2009.00405.x
Subject(s) - medicine , teicoplanin , rhodococcus equi , pneumonia , carbapenem , microbiology and biotechnology , meropenem , intensive care medicine , vancomycin , antibiotics , staphylococcus aureus , bacteria , antibiotic resistance , virulence , biology , biochemistry , gene , genetics
Rhodococcus equi is a bacterial pathogen of domestic animals that can infect immunocompromised patients, especially those with impaired cellular immunity, such as transplant recipients. No standard treatment has been established, but therapy must be prolonged, as relapses are common and can occur at the initial site or distant locations. Here we report a case of R. equi ‐associated pulmonary abscess in a renal transplant recipient successfully treated with a combination of carbapenem and teicoplanin. This combination was shown to be synergistic. It has minimal side effects in transplant recipients and appears to be an effective initial treatment for this severe infection.