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Acanthamoeba infection in a patient with chronic graft‐versus‐host disease occurring during treatment with voriconazole
Author(s) -
Kaul D.R.,
Lowe L.,
Visvesvara G.S.,
Farmen S.,
Khaled Y.A.,
Yanik G.A.
Publication year - 2008
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2008.00335.x
Subject(s) - voriconazole , medicine , acanthamoeba , graft versus host disease , hematopoietic stem cell transplantation , disease , leukemia , chronic lymphocytic leukemia , immunology , dermatology , pathology , microbiology and biotechnology , antifungal , biology
We report a case of disseminated infection with Acanthamoeba in a patient with graft‐versus‐host disease after hematopoietic stem cell transplant (HSCT) for acute lymphocytic leukemia. The infection involved the brain, skin, and lungs and occurred despite treatment with voriconazole for mold prophylaxis, and did not respond to treatment with multiple other agents reported to have activity against Acanthamoeba . To our knowledge, infection with Acanthamoeba has been reported in 4 other patients after HSCT or bone marrow transplant, and our case is the first to be diagnosed ante‐mortem.