Premium
Infectious complications in chronic graft‐versus‐host disease: a retrospective study of 145 recipients of allogeneic hematopoietic stem cell transplantation with reduced‐ and conventional‐intensity conditioning regimens
Author(s) -
Yamasaki S.,
Heike Y.,
Mori S.,
Fukuda T.,
Maruyama D.,
Kato R.,
Usui E.,
Koido K.,
Kim S.,
Tanosaki R.,
Tobinai K.,
Teshima T.,
Takaue Y.
Publication year - 2008
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2007.00291.x
Subject(s) - medicine , hematopoietic stem cell transplantation , graft versus host disease , retrospective cohort study , prednisolone , transplantation , bacteremia , hemorrhagic cystitis , pneumonia , surgery , immunology , gastroenterology , antibiotics , biology , microbiology and biotechnology
To assess infectious complications associated with chronic graft‐versus‐host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) with reduced‐ and conventional‐intensity conditioning regimens (RIC, n =91; CIC, n =54, respectively), we retrospectively analyzed data from 145 consecutive patients with cGVHD after allogeneic HSCT from a human leukocyte antigen‐matched related or unrelated donor. In the present retrospective analysis, 57% (83/145) of patients with cGVHD developed infections, with a mortality rate of 27% (22/83). The incidences of bacteremia ( n =28), central venous catheter‐related infections ( n =11), bacterial pneumonia ( n =4), invasive aspergillosis ( n =7), and adenoviral hemorrhagic cystitis ( n =8) were significantly higher in patients with prednisolone dose ≥1 mg/kg at the time of diagnosis of cGVHD. The present results suggest that infections associated with cGVHD, especially after high‐dose prednisolone, are predictive of poor outcome regardless of whether the patient received RIC or CIC.