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Rhodococcus equi lung infection in an allogeneic hematopoietic stem cell transplant recipient
Author(s) -
Cronin S.M.,
Abidi M.H.,
Shearer C.J.,
Chandrasekar P.H.,
Ibrahim R.B.
Publication year - 2008
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2007.00274.x
Subject(s) - rhodococcus equi , medicine , stem cell , ertapenem , lung , hematopoietic stem cell , immunology , hematopoietic stem cell transplantation , vancomycin , antibiotics , rhodococcus , graft versus host disease , haematopoiesis , disease , staphylococcus aureus , microbiology and biotechnology , bacteria , antibiotic resistance , biology , biochemistry , genetics , imipenem , virulence , gene
In this report, we describe a case of Rhodococcus equi lung infection diagnosed in an allogeneic hematopoietic stem cell transplant with oral graft‐versus‐host disease 3 months after stem cell infusion. The lung lesion persisted despite an approximate 3 months of vancomycin therapy, but then responded favorably to a combination of intravenous ertapenem at 1 g daily and oral rifampin at 600 mg daily for 1 month. An overview of Rhodococcus infection in transplant recipients is presented. This case and the discussed literature suggest that combination antibiotic therapy is warranted in patients with decreased humoral and cellular immunity.