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Pulmonary Nocardia and Aspergillus co‐infection in a patient with chronic graft‐versus‐host disease
Author(s) -
Hamadani M.,
Benson D.M.,
Blum W.,
Garzon R.,
Devine S.M.
Publication year - 2008
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2007.00268.x
Subject(s) - medicine , immunosuppression , nocardiosis , nocardia , aspergillosis , incidence (geometry) , hematopoietic stem cell transplantation , pentostatin , graft versus host disease , transplantation , disease , chronic granulomatous disease , immunology , biology , rituximab , physics , lymphoma , bacteria , optics , genetics
Immunosuppression and chronic graft‐versus‐host disease (GVHD) are major risk factors for the development of invasive pulmonary aspergillosis in bone marrow transplant patients. Although nocardial infections are well described in hematopoietic stem cell transplantation (HSCT) recipients, little information is available about the incidence of nocardiosis in patients with chronic GVHD after HSCT. Coexistence of invasive pulmonary aspergillosis and nocardiosis following non‐myeloablative HSCT has not been reported previously. With the increasing use of pentostatin in the treatment of chronic GVHD in future and other nucleoside analogues as preparative regimens in patients undergoing reduced‐intensity conditioning transplantation, the possibility of co‐infection with rare organisms should be kept in mind while assessing at‐risk patients.