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Caspofungin‐resistant Aspergillus flavus after heart transplantation and mechanical circulatory support: a case report
Author(s) -
Eschertzhuber S.,
VelikSalchner C.,
Hoermann C.,
Hoefer D.,
LassFlorl C.
Publication year - 2008
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2007.00252.x
Subject(s) - medicine , caspofungin , heart transplantation , aspergillus flavus , circulatory system , transplantation , intensive care medicine , cardiology , microbiology and biotechnology , voriconazole , antifungal , dermatology , biology
Invasive aspergillosis (IA) is a severe complication in the post‐transplant period in recipients of solid organs. Therefore, early diagnosis and specific therapy of fungal infections in these patients are indispensable. We report the case of a 49‐year‐old patient, who suffered from IA after cardiac transplantation, which was complicated by post‐transplant right heart failure requiring mechanical circulatory support using veno‐arterial extracorporeal membrane oxygenation and a right ventricular assist device. Despite antifungal treatment, the patient died 3 weeks after transplantation because of multi‐organ failure secondary to IA. The isolated Aspergillus strains exhibited in vitro resistance to caspofungin.