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T‐helper cell responses in liver transplant recipients: correlation with cytomegalovirus and other major infections
Author(s) -
Singh N.,
Gayowski T.,
Wagener M.M.,
Zeevi A.
Publication year - 2004
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2004.00056.x
Subject(s) - serostatus , medicine , cytomegalovirus , concanavalin a , immunology , liver transplantation , serology , transplantation , herpesviridae , viral load , virus , viral disease , antibody , biology , biochemistry , in vitro
Mitogen concanavalin A (ConA) response and cytomegalovirus (CMV)‐specific memory response were assessed in 24 liver transplant recipients and compared with healthy subjects. Transplant recipients as compared to healthy subjects had a lower CMV memory response at 2 weeks ( P =0.023), and at 1 month ( P =0.06), but a comparable response at 3 months. CMV recipient+/donor+(R+/D+) patients had the greatest increase in CMV‐specific memory response at 2–3 months as compared to all other groups. Within this R+/D+ group, CMV‐specific memory response was significantly more robust in patients who never had CMV infection as compared to those who developed CMV infection ( P =0.035). ConA response at 2 weeks was significantly lower in patients with major infections as compared to those without them (SI 5.4 vs. 38.1, P =0.039). Thus, reconstitution of CMV‐specific T‐helper cell response was distinct for subsets of liver transplant recipients based on the recipient and donor CMV serostatus. Impairment in proliferative response to ConA identified a subgroup of patients with major infections after liver transplantation.