Premium
Deep sinus aspergillosis in a liver transplant recipient successfully treated with a combination of caspofungin and voriconazole
Author(s) -
Tsiodras S.,
Zafiropoulou R.,
Giotakis J.,
Imbrios G.,
Antoniades A.,
Manesis E.K.
Publication year - 2004
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2004.00039.x
Subject(s) - medicine , voriconazole , caspofungin , aspergillosis , surgery , liver transplantation , enucleation , itraconazole , transplantation , dermatology , antifungal , immunology
Abstract: We describe the rare case of a diabetic patient who was successfully treated for cytomegalovirus viremia and leishmaniasis following liver transplantation for hepatitis C virus‐related cirrhosis, but also developed invasive sinus Aspergillus infection, while still on liposomal amphotericin B (AmBisome). The patient refused radical surgery including eye enucleation, and received a combination of intravenous caspofungin and voriconazole, along with repeated, conservative, local surgical debridement. At follow‐up, 15 months after the onset of sinusitis, the patient remains culture‐negative, fully active, and without evidence of local recurrence.