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Pneumonia and mesenteric lymphadenopathy caused by disseminated Penicillium marneffei infection in a cadaveric renal transplant recipient
Author(s) -
Chan Y.H.,
Wong K.M.,
Lee K.C.,
Kwok P.C.H.,
Chak W.L.,
Choi K.S.,
Chau K.F.,
Li C.S.
Publication year - 2004
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2004.00038.x
Subject(s) - penicillium marneffei , medicine , dimorphic fungus , pneumonia , amphotericin b , mucormycosis , opportunistic infection , itraconazole , pathology , immunology , dermatology , coinfection , human immunodeficiency virus (hiv) , viral disease , antifungal , genetics , biology , yeast
A 38‐year‐old cadaveric kidney transplant recipient presented with fever, pneumonia, and mesenteric lymphadenopathy 9 months after transplant. Blood culture, bone marrow culture, and fine‐needle aspiration cytology of mesenteric lymph nodes confirmed the diagnosis of disseminated Penicillium marneffei infection. He recovered after receiving parenteral amphotericin B followed by oral itraconazole therapy. P. marneffei infection is a dimorphic fungal opportunistic infection endemic in Southeast Asia, southern China, Taiwan, and Hong Kong. It has been well reported in human immunodeficiency virus (HIV)‐positive patients in the endemic areas, and also in other immunocompromised patients. This diagnosis must be considered for all febrile transplant recipients who have the relevant clinical features and travel history to Southeast Asia. Prompt treatment with anti‐fungal therapy improves the survival and outcome of these patients.