Premium
Aspergillus vertebral osteomyelitis after simultaneous kidney–pancreas transplantation
Author(s) -
Salvalaggio P.R.O.,
Bassetti M.,
Lorber M.I.,
Micheletto G.C.,
Friedman A.L.,
Andriole V.T.,
Basadonna G.P.
Publication year - 2003
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2003.00030.x
Subject(s) - medicine , caspofungin , aspergillosis , vertebral osteomyelitis , transplantation , surgery , osteomyelitis , kidney transplantation , complication , organ transplantation , amphotericin b , antifungal , dermatology , immunology
Aspergillus osteomyelitis is a rare complication of invasive aspergillosis after organ transplantation. This is the report of a 46‐year‐old man who underwent a simultaneous pancreas and kidney transplantation, complicated by an Aspergillus osteomyelitis and diskitis of the lumbar spine. Prompt diagnosis with needle biopsy, followed by antifungal therapy using caspofungin, a new antifungal agent recommended for the treatment of refractory aspergillosis, in combination with amphotericin B and an early surgical intervention led to clinical resolution of the infection. Reported cases of spinal aspergillosis after transplantation are reviewed in terms of clinical presentation, risk factors, therapeutic options, and outcome.