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Separases: biochemistry and function
Author(s) -
Moschou Panagiotis N.,
Bozhkov Peter V.
Publication year - 2012
Publication title -
physiologia plantarum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.351
H-Index - 146
eISSN - 1399-3054
pISSN - 0031-9317
DOI - 10.1111/j.1399-3054.2011.01550.x
Subject(s) - separase , biology , microbiology and biotechnology , yeast , eukaryotic cell , function (biology) , sister chromatids , metaphase , cell cycle , anaphase promoting complex , computational biology , genetics , anaphase , cell , chromosome , gene
Tight regulation of cell cycle is of critical importance for eukaryotic biology and is achieved through a combined action of a large number of highly specialized proteins. Separases are evolutionarily conserved caspase‐like proteases playing a crucial role in cell cycle regulation, as they execute sister chromatid separation at metaphase to anaphase transition. In contrast to extensively studied yeast and metazoan separases, very little is known about the role of separases in plant biology. Here we describe the molecular mechanisms of separase‐mediated chromatid segregation in yeast and metazoan models, discuss new emerging but less‐understood functions of separases and highlight major gaps in our knowledge about plant separases.