Premium
Inhibition of early steps of de novo fatty‐acid biosynthesis by different xenobiotica
Author(s) -
Focke Manfred,
Feld Andrea,
Lichtenthaler Hartmut K.
Publication year - 1991
Publication title -
physiologia plantarum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.351
H-Index - 146
eISSN - 1399-3054
pISSN - 0031-9317
DOI - 10.1111/j.1399-3054.1991.tb02138.x
Subject(s) - cerulenin , biosynthesis , biochemistry , acetyl coa carboxylase , pyruvate carboxylase , fatty acid synthesis , chemistry , fatty acid , enzyme , fatty acid synthase , biology
The importance of the early steps of de novo fatty‐acid biosynthesis is discussed in terms of rate‐limiting enzymic reactions with respect to their inhibition by xenobiotics. The inhibitory spectra of allicin as an inhibitor of the acetyl‐CoA‐synthase, two classes of graminicides (cyclohexane‐1,3‐diones and aryloxyphenoxypropionic acids) as inhibitors of acetyl‐CoA‐carboxylase, and the two antibiotics cerulenin and thiolactomycin, which affect the condensing step in fatty‐acid biosynthesis, are compared.