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Imipramine affects circadian leaf movements in Oxalis regnellii
Author(s) -
Rinnan T.,
Johnsson A.,
Götestam K. G.
Publication year - 1984
Publication title -
physiologia plantarum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.351
H-Index - 146
eISSN - 1399-3054
pISSN - 0031-9317
DOI - 10.1111/j.1399-3054.1984.tb00363.x
Subject(s) - imipramine , circadian rhythm , period (music) , phase response curve , tricyclic , pharmacology , chemistry , endocrinology , medicine , biology , circadian clock , physics , alternative medicine , pathology , acoustics
The sensitivity of the circadian leaf movement of Oxalis regnellii Mig. to imipramine (a tricyclic dibenzazepine) was investigated. Imipramine, like Li + , is used as a therapeutic agent against depressive disorders in man. The therapeutic effects of the two substances might be mediated via effects on basic circadian rhythms and the cellular level. It was indeed possible to influence the circadian movement of Oxalis by imipramine; pulses (10 −3 M , 4h) phase shifted the rhythms and caused advances. A phase response curve is presented. No period change of the movements was caused by permanent presence of imipramine (5 ‐ 10 −5 or 10 −5 M ). The nature of the imipramine‐induced phase shift is discussed and compared with Li −1 effects on the same circadian system.