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Chronic immune‐mediated axonal polyneuropathy following umbilical cord blood transplant for childhood‐onset cerebral adrenoleukodystrophy
Author(s) -
Shibata Minoru,
Kato Takeo,
Awaya Tomonari,
Adachi Souichi,
Heike Toshio
Publication year - 2012
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2012.01748.x
Subject(s) - medicine , polyneuropathy , complication , sural nerve , adrenoleukodystrophy , umbilical cord , transplantation , surgery , immunology , peroxisome , receptor
Shibata M, Kato T, Awaya T, Adachi S, Heike T. Chronic immune‐mediated axonal polyneuropathy following umbilical cord blood transplant for childhood‐onset cerebral adrenoleukodystrophy. Abstract: Peripheral polyneuropathy is an unusual complication after organ transplantation and HSCT. The present study describes the case of an eight‐yr‐old boy diagnosed with ALD who underwent HLA‐matched UCBT under a reduced‐intensity conditioning regimen and developed progressive walking difficulty and hand clumsiness 11 months after transplantation. These symptoms were associated with cGVHD, identified as immune‐mediated axonopathy by electrophysiological examination and sural nerve biopsy. Peripheral polyneuropathy should be kept in mind as a complication of GVHD.