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Surgical management of stem cell transplantation‐related complications in children
Author(s) -
Lieber Justus,
Hauch Holger,
Lang Peter,
Handgretinger Rupert,
Blumenstock Gunnar,
Seitz Guido,
Warmann Steven W.,
Fuchs Jörg
Publication year - 2012
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2012.01708.x
Subject(s) - medicine , surgery , transplantation , hematopoietic stem cell transplantation
Lieber J, Hauch H, Lang P, Handgretinger R, Blumenstock G, Seitz G, Warmann SW, Fuchs J. Surgical management of stem cell transplantation‐related complications in children. Abstract: HSCT is an established treatment option for some children with life‐threatening diseases, but complications remain a major cause of morbidity and mortality. This retrospective data analysis addresses the surgical issues of children with HSCT‐related complications. Between 2002 and 2008, HSCT was performed in 240 children for leukemias/lymphomas (n=135), solid tumors (n=59), immunodeficiencies (n=20), lipid storage diseases (n=10), autoimmune diseases (n=9), and others (n=7). HSCT‐related complications requiring surgery occurred in 24 cases (10%) and most often in the leukemias/lymphomas group (18/24 cases): HC (cystoscopic irrigation, n=7), pulmonary aspergilloses (resection, n=7), bone necroses (core decompression, n=3), GvHD bowel (colostomy/PEG, n=2), ICH (drainage, n=2), bilateral kidney abscess (nephrectomies/renal transplantation, n=1), aspergillosis of the maxillary sinus (decompression, n=1), and post‐traumatic wound healing disorder (meshed skin transplantation, n=1). Survival was 50% in the group with surgery and 62% in the group without (p=0.275). Even though this difference was not statistically significant, surgical intervention should be encouraged in all cases to achieve favorable results.