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An unusual manifestation of post‐transplant lymphoproliferative disorder in the lip after pediatric heart transplantation
Author(s) -
Chen C.,
AkanayDiesel S.,
Schuster F. R.,
Klee D.,
Schmidt K. G.,
Donner B. C.
Publication year - 2012
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2012.01673.x
Subject(s) - medicine , lymphoproliferative disorders , post transplant lymphoproliferative disorder , heart transplantation , transplantation , pediatrics , surgery , pathology , lymphoma , rituximab
Chen C, Akanay‐Diesel S, Schuster FR, Klee D, Schmidt KG, Donner BC. An unusual manifestation of post‐transplant lymphoproliferative disorder in the lip after pediatric heart transplantation.
Pediatr Transplantation 2012. © 2012 John Wiley & Sons A/S. Abstract: PTLD is a serious and frequently observed complication after solid organ transplantation. We present a six‐yr‐old girl with a rapidly growing, solid tumor of the lip four yr after orthotopic heart transplantation, which was classified as monomorphic PTLD with the characteristics of a diffuse large B‐cell lymphoma. Treatment with reduction in immunosuppression, ganciclovir, and anti B‐cell monoclonal antibody (rituximab) resulted in full remission since 12 months. To the best of our knowledge, this report is the first description of PTLD in the lip in a pediatric patient after heart transplantation in the English literature.