Premium
Mitochondrial electron transport chain deficiency, cardiomyopathy, and long‐term cardiac transplant outcome
Author(s) -
Golden Alana S.,
Law Yuk M.,
Shurtleff Hillary,
Warner Molly,
Saneto Russell P.
Publication year - 2012
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2011.01635.x
Subject(s) - medicine , dilated cardiomyopathy , cardiomyopathy , immunosuppression , transplantation , heart transplantation , population , oxidative phosphorylation , mitochondrial dna , cardiology , heart failure , genetics , gene , biochemistry , environmental health , biology , chemistry
Golden AS, Law YM, Shurtleff H, Warner M, Saneto RP. Mitochondrial electron transport chain deficiency, cardiomyopathy, and long‐term cardiac transplant outcome. Abstract: Organ transplantation in multisystemic mitochondrial cytopathies is usually not performed because of perceived untoward complications. We report three patients with demonstrated oxidative phosphorylation defects and dilated cardiomyopathy who underwent cardiac transplant. All three patients tolerated immunosuppression medications and have had an excellent long‐term outcome. Our results suggest that with proper patient selection in this population, cardiac transplantation is feasible and can have good outcomes.