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A child with BK virus infection: Inadequacy of current therapeutic strategies
Author(s) -
Pereira Tanya,
Rojas Claudia P.,
GarciaBuitrago Monica T.,
Chandar Jayanthi,
Abitbol Carolyn,
Seeherunvong Wacharee,
Rusconi Paolo,
Bruce Jocelyn H.,
Zilleruelò Gaston
Publication year - 2012
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2011.01602.x
Subject(s) - cidofovir , medicine , viral load , bk virus , transplantation , disease , virus , virology , immunology , intensive care medicine , kidney transplantation
Pereira T, Rojas CP, Garcia‐Buitrago MT, Chandar J, Abitbol C, Seeherunvong W, Rusconi P, Bruce JH, Zilleruelò G. A child with BK virus infection: Inadequacy of current therapeutic strategies.
Pediatr Transplantation 2011. © 2011 John Wiley & Sons A/S. Abstract: In this report, we describe the development of BKVN in the native kidneys of a child with a cardiac transplant. Elevated BK viral DNA load by PCR necessitated a prolonged course of treatment with escalating doses of cidofovir. Despite a reduction in plasma BK viral load, the infection evolved into an invasive CNS disease, resulting in rhomboencephalitis. This case highlights the need for awareness of the possibility of developing multiorgan complications from BKV infection. The current treatment options for BKV tissue invasive disease are inadequate and need to be improved.