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Premium Successful sirolimus rescue in tacrolimus‐induced thrombotic microangiopathy after living‐related liver transplantation
Author(s)
Czubkowski Piotr,
Pawłowska Joanna,
Jankowska Irena,
Teisseyre Mikołaj,
Kamińska Diana,
Markiewicz Małgorzata,
Ryżko Józef
Publication year2012
Publication title
pediatric transplantation
Resource typeJournals
PublisherBlackwell Publishing Ltd
Czubkowski P, Pawłowska J, Jankowska I, Teisseyre M, Kamińska D, Markiewicz M, Ryżko J. Successful sirolimus rescue in tacrolimus‐induced thrombotic microangiopathy after living‐related liver transplantation. Pediatr Transplantation 2011: 00: 000–000. © 2011 John Wiley & Sons A/S. Abstract:  TMA is a rare complication of tacrolimus. Disruption of endothelial cells, platelet aggregation, and intravascular mechanical fragmentation of red cells are core mechanisms of injury; however, exact pathways of toxicity are not clear. The clinical presentation may vary but TMA is a potentially life‐threatening condition usually demanding aggressive treatment. We present the case of TMA in a child after living‐related liver transplantation (LRLTx) on tacrolimus‐based immunosuppressive regiment successfully converted to sirolimus.
Subject(s)complication , disease , immunology , liver transplantation , medicine , pathology , sirolimus , tacrolimus , thrombotic microangiopathy , transplantation
Language(s)English
SCImago Journal Rank0.457
H-Index69
eISSN1399-3046
pISSN1397-3142
DOI10.1111/j.1399-3046.2011.01601.x

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