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Successful sirolimus rescue in tacrolimus‐induced thrombotic microangiopathy after living‐related liver transplantation
Author(s) -
Czubkowski Piotr,
Pawłowska Joanna,
Jankowska Irena,
Teisseyre Mikołaj,
Kamińska Diana,
Markiewicz Małgorzata,
Ryżko Józef
Publication year - 2012
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2011.01601.x
Subject(s) - tacrolimus , sirolimus , thrombotic microangiopathy , medicine , liver transplantation , transplantation , complication , microangiopathy , gastroenterology , diabetes mellitus , endocrinology , disease
Czubkowski P, Pawłowska J, Jankowska I, Teisseyre M, Kamińska D, Markiewicz M, Ryżko J. Successful sirolimus rescue in tacrolimus‐induced thrombotic microangiopathy after living‐related liver transplantation. Pediatr Transplantation 2011: 00: 000–000. © 2011 John Wiley & Sons A/S. Abstract: TMA is a rare complication of tacrolimus. Disruption of endothelial cells, platelet aggregation, and intravascular mechanical fragmentation of red cells are core mechanisms of injury; however, exact pathways of toxicity are not clear. The clinical presentation may vary but TMA is a potentially life‐threatening condition usually demanding aggressive treatment. We present the case of TMA in a child after living‐related liver transplantation (LRLTx) on tacrolimus‐based immunosuppressive regiment successfully converted to sirolimus.