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Donor cell‐derived acute myeloid leukemia after second allogenic cord blood transplantation in a patient with Fanconi anemia
Author(s) -
Gustafsson Britt,
Moell Jacob,
LeBlanc Katarina,
Barbany Gisela,
Söderhäll Stefan,
Winiarski Jacek
Publication year - 2012
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2011.01584.x
Subject(s) - medicine , umbilical cord , transplantation , fanconi anemia , cord blood , umbilical cord blood transplantation , hematopoietic stem cell transplantation , myeloid leukemia , savior sibling , surgery , anemia , leukemia , stem cell , haematopoiesis , immunology , dna repair , biochemistry , chemistry , genetics , biology , gene
Gustafsson B, Moell J, LeBlanc K, Barbany G, Söderhäll S, Winiarski J. Donor cell‐derived acute myeloid leukemia after second allogenic cord blood transplantation in a patient with Fanconi anemia. Pediatr Transplantation 2011. © 2011 John Wiley & Sons A/S. Abstract: DCL following hematopoietic stem cell transplantation has been reported in approximately 5% of all leukemic relapses. There have been several reports on DCL, mainly AML after umbilical cord blood transplantation. In this case study, we present a young boy diagnosed with Fanconi anemia who underwent an umbilical cord blood transplantation. Because of the graft failure, he was retransplanted one month later, also with a cord blood transplant. Two years after the second transplant, he developed AML, where 100% of the cells were of female donor origin. The donor, a now 14‐yr‐old female, was recently reported healthy.